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The hierarchy of evidence from from highest to lowest:
- Secondary, pre-appraised, or filtered:
- Clinical Practice Guidelines
- Meta-Analyses & Systematic Reviews
- Primary Studies:
- Randomized Controlled Trial (Prospective, tests treatment)
- Observational Studies:
- Cohort Studies (Prospective, exposed cohort is observed for outcome)
- Case Control Studies (Retrospective, subjects already of interest looking for risk factors)
- No design:
- Case Report or Case Series, Narrative Reviews, Expert Opinions, Editorials
- No humans involved:
- Animal and Laboratory Studies